I've posted in quite a few threads on various webmaster forums over the years regarding dealing with the adblock issue.
The solutions have ranged from simply detecting adblock is used and putting a pop up to the user to simply denying them access to the site altogether.
IMHO the best way to deal with it is to use an adblock detection script and place a popup on the site which they can close or have to wait x seconds before they can close it reminding them that your site depends on ads to keep the site going.
You don't want to deny people access to your site just because they can't use it unless they have ads showing.
But you might be surprised of the amount of people that turn off ad disabling if you just polite ask them too in some way.
If your site is WordPress, there are some WordPress plugins that can do something like this.
Just search the plugin repo for them
https://wordpress.org/plugins/tags/adblock
There are ones that pop up a message to users asking them to unblock your site if they use the site more than x amount of times and can give them x amount of notices.
There are ones that replace the ads with a message also. But these are basically the same as the ones that disable AdBlocker and that is not the desired effect.
The one you want to use if any, is the one that shows a small site message (like an unobtrusive and easily closable popup).
Just Google "
Show Message to AdBlock users" and you can find some novel ideas.
And some other useful resources I've used in the past
http://stackoverflow.com/questions/4869154/how-to-detect-adblock-on-my-website
http://www.labnol.org/internet/alternate-content-for-adblock/28602/
Good luck!